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In CKD stages 3–5, progressively higher 25(OH)D levels are:20

  • Associated with lower PTH concentrations
  • Not associated with increased rates of hypercalcaemia or hyperphosphataemia

 

The effect of 25(OH)D to reduce PTH does not decrease until 25(OH)D levels of 42–48 ng/mL (105–120 nmol/L).20

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TO CONTROL SHPT, A 25(OH)D LEVEL OF
42-48 NG/ML (105-120 NMOL/L) IS REQUIRED20

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25(OH)D: 25-hydroxyvitamin D; CKD: chronic kidney disease; PTH: parathyroid hormone; SHPT: secondary hyperparathyroidism.